Anastrozole: Uses, Side Effects & Warnings

Generic name: anastrozole [ an-as-troe-zole ]

Drug class: Aromatase inhibitors, Hormones / antineoplastics

Dosage form: oral tablet (1 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Arimidex

What is Anastrozole?

Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).

Anastrozole may also be used for purposes not listed in this medication guide.

Warnings

Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath.

How should I take Anastrozole

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Anastrozole is usually taken once per day. Follow your doctor's dosing instructions very carefully.

You may take anastrozole with or without food.

You may need to keep taking this medication for up to 5 years. Follow your doctor's instructions.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Breast Cancer:

Initial dose: 1 mg orally taken once a day
Duration of therapy: Until tumor progression (treatment of advanced breast cancer); unknown (adjuvant treatment of early breast cancer)

Uses:
-Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer;
-First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer;
-Second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Detailed Anastrozole dosage information

Anastrozole Dosage information (more detail)

Before Taking

You should not use anastrozole if you are allergic to it, or if you have not yet completed menopause.

Anastrozole is not approved for use in men or children.

You should not take anastrozole if you also take tamoxifen.

Tell your doctor if you have ever had:

• heart problems;

• coronary artery disease (clogged artery disease);

• high cholesterol; or

• osteoporosis or low bone mineral density.

Hormonal cancer treatment can weaken your bones. You may be more likely to have a broken bone while using anastrozole. Talk with your doctor about ways to keep your bones healthy.

Although it is not likely that a postmenopausal woman would be pregnant, anastrozole may harm an unborn baby. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control if you are not past menopause. Keep using birth control for at least 3 weeks after your last dose of anastrozole. Tell your doctor if you become pregnant.

Do not breastfeed while using anastrozole, and for at least 2 weeks after your last dose.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Anastrozole?

Avoid driving or hazardous activity until you know how anastrozole will affect you. Your reactions could be impaired.

Anastrozole side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Anastrozole may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries). Seek medical attention if you have new or worsening chest pain, or if you feel short of breath.

Anastrozole may cause serious side effects. Call your doctor at once if you have:

• shortness of breath (even with mild exertion), swelling, rapid weight gain;

• numbness, prickly feeling, pain, or weakness in your hands or wrists;

• symptoms of bone fracture--bruising, swelling, tenderness, pain that worsens with movement;

• liver problems--right-sided upper stomach pain, yellowing of your skin or eyes, and not feeling well; or

• signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects of anastrozole may include:

• numbness, tingling, or tickling feeling in your skin;

• hot flashes;

• weakness;

• joint pain or stiffness;

• bone pain, risk of fracture;

• swelling in your arms, legs, or feet;

• sore throat, cough, shortness of breath;

• headache, back pain;

• depression, sleep problems (insomnia);

• high blood pressure;

• nausea, vomiting; or

• rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Anastrozole Side Effects

What other drugs will affect Anastrozole?

Anastrozole may not work as well if you take it together with an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings or vaginal suppositories).

Other drugs may affect anastrozole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to anastrozole.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Source: https://themeditary.com/drug/anastrozole-35.html?utm_source=4_blogger_source&utm_medium=4_blogger_medium&utm_campaign=4_blogger_cam

Drug Class: Aromatase inhibitors

Post by: TheMediTary.Com